Meduslabs — Evidence-based health research
HomeANXIETYMultiple Sclerosis: Inflammation, Diet, and Myelin Support
Key Takeaways

This article is informational only and not medical advice. Multiple sclerosis is a serious condition requiring professional medical care — the dietary and lifestyle factors discussed here are presented as the evidence-based perspective on reducing inflammation and supporting the body, not as a treatment or cure.

Multiple sclerosis and the nervous system

Why do we get multiple sclerosis?

Global prevalence of multiple sclerosis map

One of the most widespread views is vitamin D deficiency, since on a world map of MS prevalence one can "see" that cases seem to increase moving away from the equator. But this theory is evidently not the whole story — perhaps only scratching the surface. The best counterexample is Australia: prevalence is fairly high. Are they short of sun? The picture points elsewhere.

What raises inflammation (activates immunity) in the body

The causes of MS have been (and still are) studied. A genetic factor has not been established. For a long time a virus, bacterium or other parasite was suspected (measles, herpesvirus-6, Epstein-Barr, Chlamydia pneumoniae, Candida), but a link has also not been established.2 MS cases worldwide are growing not by percentages but by hundreds of thousands. The common thread the medix perspective emphasises is chronic inflammation — and what we eat is the largest controllable driver.

The omega-3 to omega-6 ratio

Omega-3 to omega-6 ratio for inflammation

There is agreement that the omega ratio should be about 1:1.4 How much fish do you eat? Omega-3 (from fish and seafood) reduces inflammation,7 while omega-6 increases it.11 Omega-6 is in all vegetable oils, in any baked good, and in processed and ready-to-eat foods. Most people's ratio is badly skewed toward omega-6 — correcting it is a foundational step.

Sugar and multiple sclerosis

Sugar raises inflammation in the body.18 Consuming sugar (simple carbohydrates — usually anything sweet, and worse, artificial sweeteners) produces harmful compounds called AGEs (advanced glycation end products), which form when fats or proteins bind with blood sugar and drive oxidative damage and inflammation.

The biggest enemies driving multiple sclerosis

Gliadin, glutenin and zonulin. If anything is to be blamed for MS, these substances are the prime suspects.38 It has long been recognised that gluten causes gastrointestinal inflammation,41 and scientists increasingly document how gluten triggers whole-body inflammation even in people without coeliac disease or diagnosed gluten allergy42 — by prompting the release of zonulin, which opens the junctions between gut cells ("leaky gut").

What to eat with multiple sclerosis

As described, you need to give up everything that causes inflammation and eat what reduces it. Correct the omega-3/omega-6 ratio. Simple carbohydrates leave the diet — anything even slightly sweet. At first shopping takes longer (reading labels), but you soon learn your products and it becomes quick. Choose wild fatty fish, quality animal fats, leafy and non-starchy vegetables, and fermented foods.

How to maximally reverse the consequences of MS and grow myelin?

First, you need to repair the "leaky" gut and the blood-brain barrier. You need butyrate. Gut cells use butyrate as fuel; it improves mitochondrial function, prevents toxins from entering through the gut wall, and reduces inflammation. Where does butyrate come from? The good bacteria in your gut produce it — so your job is to feed them daily (fibre from vegetables, fermented foods) so they can multiply and thrive.

Supplements with multiple sclerosis

Two compounds are worth mentioning — one protects and calms the brain, the other prompts it to recover and grow. Vitexin, an active compound found in many plants, is studied for protecting and calming the brain94 and has been trialled, with promising results, in multiple sclerosis.95 The second, the Hericium erinaceus medicinal mushroom,97 is studied for promoting nerve growth factor (NGF) and myelin regeneration. Together they pair brain protection with nerve restoration. Always discuss any approach with your doctor — these do not replace prescribed MS treatment.

Related supplement

Vitexin is studied for protecting the brain and trialled in MS; Hericium erinaceus is studied for NGF and myelin regeneration - examined as complementary support.

Vitexin 90 by Zenius Labs™ →
Is multiple sclerosis caused by vitamin D deficiency?

Vitamin D deficiency is a common theory, based on MS prevalence increasing away from the equator, but it is not the whole story — Australia, for example, has high prevalence despite ample sun. The medix perspective emphasises chronic inflammation, driven heavily by diet, as a more complete explanation. MS requires professional medical care.

What dietary factors are linked to multiple sclerosis inflammation?

A skewed omega-3 to omega-6 ratio (too much omega-6 from vegetable oils and processed food), sugar and simple carbohydrates (which form inflammatory AGEs), and gluten (gliadin/glutenin triggering zonulin release and "leaky gut") are highlighted as inflammatory drivers.

What is butyrate and why does it matter in MS?

Butyrate is a compound produced by good gut bacteria. Gut cells use it as fuel; it improves mitochondrial function, helps seal the gut wall against toxins, and reduces inflammation — supporting the gut and blood-brain barrier. You support it by feeding gut bacteria with fibre and fermented foods.

Which supplements are studied for multiple sclerosis support?

Two are highlighted: vitexin (studied for protecting and calming the brain, trialled in MS with promising results) and Hericium erinaceus / Lion's Mane (studied for nerve growth factor and myelin regeneration). They are complementary support and do not replace prescribed MS treatment — discuss with your doctor.

References
  1. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. PubMed
  2. The China Study — nutrition research. UC Press. UC Press
  3. Essential fatty acids and inflammatory disease. Gamalift. PDF
  4. Omega-3 fatty acids and inflammation markers. Journal of the American College of Nutrition. Taylor & Francis
  5. Omega-3 fatty acids for major depressive disorder and neuroinflammation. Brain, Behavior, and Immunity. ScienceDirect
  1. Inflammation and atherosclerosis — mechanisms and therapeutic approaches. Current Atherosclerosis Reports. Springer
  2. Omega-3 supplementation and neuroinflammation. Brain, Behavior, and Immunity. ScienceDirect
  3. Health implications of high dietary omega-6 polyunsaturated fatty acids. ncbi.nlm.nih.gov
  4. Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. Biochem Pharmacol. PubMed
  5. An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity. Nutrients. PMC
  6. Neuroprotective effects of medicinal mushroom extracts. Experimental and Toxicologic Pathology. ScienceDirect
  7. Dietary omega-3 and omega-6 fatty acids compete in producing tissue compositions and tissue responses. Mil Med. PubMed
  8. Essential Fatty Acids — research overview. Linus Pauling Institute. Oregon State
  9. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. Br J Nutr. PubMed
  10. Differences and similarities in hepatic lipogenesis, gluconeogenesis and oxidative imbalance in mice fed diets rich in fructose or sucrose. Food Funct. PubMed
  11. Sugar-sweetened soda consumption and risk of developing rheumatoid arthritis in women. Am J Clin Nutr. PubMed
  12. A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway. Cancer Res. PubMed
  13. Sucrose counteracts the anti-inflammatory effect of fish oil in adipose tissue and increases obesity development in mice. PLoS One. PubMed
  14. Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. JPEN J Parenter Enteral Nutr. PubMed
  15. Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized controlled trial. Am J Clin Nutr. PubMed
  16. Consumption of sucrose-sweetened soft drinks increases plasma levels of uric acid in overweight and obese subjects: a 6-month randomised controlled trial. Eur J Clin Nutr. PubMed
  17. Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation. Lipids Health Dis. PMC
  18. Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity. Diabetes Metab Syndr Obes. PubMed
  19. Carbohydrate nutrition and inflammatory disease mortality in older adults. Am J Clin Nutr. PubMed
  20. High-glycemic index carbohydrate increases nuclear factor-kappaB activation in mononuclear cells of young, lean healthy subjects. Am J Clin Nutr. PubMed
  21. Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions. Arterioscler Thromb. PubMed
  22. Causality of small and large intestinal microbiota in weight regulation and insulin resistance. Mol Metab. PubMed
  23. Added sugar intake and cardiovascular diseases mortality among US adults. JAMA Intern Med. PubMed
  24. Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering. Nutr Metab (Lond). PubMed
  25. Sugar sweetened beverages and cardiometabolic health. Curr Opin Cardiol. PubMed
  26. Impact of sugar-sweetened beverages on blood pressure. Am J Cardiol. PubMed
  27. Sugar addiction comparable to cocaine — research findings. ScienceDaily. ScienceDaily
  28. Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev. PubMed
  29. Multiple Sclerosis — symptoms, causes and risk factors. Mayo Clinic. Mayo Clinic
  30. [Gluten-related disorders and demyelinating diseases]. Med Clin (Barc). PubMed
  31. Celiac disease with cerebral and peripheral nerve involvement mimicking multiple sclerosis. J Med Life. PubMed
  32. HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing. J Biomed Sci. PubMed
  33. Gluten causes gastrointestinal inflammation — research compilation. Google Scholar. Google Scholar
  34. Gluten Psychosis: Confirmation of a New Clinical Entity. Nutrients. PMC
  35. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology. PMC
  36. Intestinal permeability and zonulin release by gliadin. Scandinavian Journal of Gastroenterology. Taylor & Francis
  37. Gliadin and intestinal permeability in celiac and non-celiac patients. Clinical Gastroenterology and Hepatology. ScienceDirect
  38. Gliadin binding to CXCR3 causes zonulin release. Journal of Pediatric Gastroenterology and Nutrition. LWW
  39. Zonulin as a biomarker of intestinal barrier dysfunction. Autoimmunity. Taylor & Francis
  40. Cytokine modulation by immunomodulatory polysaccharides. Journal of Clinical Immunology. Springer
  41. Pioneering researcher Alessio Fasano on gluten, autoimmunity and leaky gut. Chris Kresser. Chris Kresser
  42. Intestinal barrier dysfunction in autoimmune disease development. Lund University. Lund University
  43. Neuroprotective mechanisms of natural compounds in neurodegeneration. Journal of Cellular and Molecular Medicine. Wiley
  44. Nerve growth factor synthesis induced by Hericium erinaceus erinacines. Journal of Neurochemistry. Wiley
  45. Fixing leaky blood-brain barrier may help treat multiple sclerosis. Columbia University. Columbia
  46. Blood-brain barrier permeability precedes clinical MS symptoms. Cell Reports. Cell Reports
  47. Blood-brain barrier dysfunction in multiple sclerosis. Brain (Oxford). Oxford Academic
  48. IgA antibodies against gliadin and gluten in multiple sclerosis. IgLabo. IgLabo
  49. Gluten sensitivity in multiple sclerosis: experimental myth or clinical truth? Ann N Y Acad Sci. PubMed
  50. IgA antibodies against gliadin and gluten in multiple sclerosis. Acta Neurol Scand. PubMed
  51. A case of multiple sclerosis and celiac disease. Case Rep Neurol Med. PMC
  52. Herbal medicine approaches in multiple sclerosis management. Journal of HerbMed Pharmacology. ScienceDirect
  53. Antibody testing for gluten sensitivity and autoimmune triggers. Cyrex Labs. Cyrex Labs
  54. International food industry and wheat production — modern agriculture. The Guardian. The Guardian
  55. The gliadin effect — how modern wheat affects health. Wheat Belly. Wheat Belly
  56. Modern wheat — a health nightmare? Research evidence. Healthline. Healthline
  57. Modern wheat vs ancient grains — structural differences. Grainstorm. Grainstorm
  58. Modern wheat as a chronic poison — expert analysis. CBS News. CBS News
  59. Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease. Theor Appl Genet. PMC
  60. Butyrate and intestinal barrier function. Scandinavian Journal of Gastroenterology. Taylor & Francis
  61. Search for atoxic cereals: a single blind, cross-over study on the safety of a single dose of Triticum monococcum, in patients with celiac disease. BMC Gastroenterol. PMC
  62. Opioid peptides derived from food proteins. The exorphins. J Biol Chem. PubMed
  63. Demonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates. Peptides. PubMed
  64. Effect of gluten exorphins A5 and B5 on the postprandial plasma insulin level in conscious rats. Life Sci. PubMed
  65. Prolactin and growth hormone response to intracerebroventricular administration of the food opioid peptide gluten exorphin B5 in rats. Life Sci. PubMed
  66. Prolamin — plant storage proteins and gluten components. Wikipedia. Wikipedia
  67. Butyric acid — short-chain fatty acid and gut health. Wikipedia. Wikipedia
  68. Hericium erinaceus promotes peripheral nerve regeneration. Neuroscience Letters. ScienceDirect
  69. Lipid peroxidation and antioxidant status in multiple sclerosis. Life Sciences. ScienceDirect
  70. Gut microbiota composition and multiple sclerosis. Journal of Medical Microbiology. Microbiology Society
  71. Essential fatty acid composition in multiple sclerosis brain tissue. Life Sciences. ScienceDirect
  72. Gut microbiota and CNS autoimmunity — commensal bacteria influence. Cell. Cell
  73. Essential fatty acids and CNS function — nutritional perspectives. Nutrition Bulletin. Wiley
  74. Omega-3 fatty acids in health and disease — comprehensive review. Critical Reviews in Food Science. Taylor & Francis
  75. Complementary and integrative medicine approaches in MS. Seminars in Integrative Medicine. ScienceDirect
  76. Diet quality and symptom severity in multiple sclerosis. European Journal of Clinical Nutrition. ScienceDirect
  77. Butyrate and other short-chain fatty acids as modulators of immunity. Current Opinion in Clinical Nutrition. LWW
  78. Gut microbiome linked to CNS autoimmunity in multiple sclerosis. Nature Communications. Nature
  79. Emerging Concepts on the Gut Microbiome and Multiple Sclerosis. J Interferon Cytokine Res. PMC
  80. Hericium erinaceus polysaccharides and immune modulation. PLOS ONE. PLOS ONE
  81. Neurotrophin signaling pathways in CNS repair and plasticity. Trends in Neurosciences. ScienceDirect
  82. Brain connectivity changes and neuroplasticity mechanisms. NeuroImage. ScienceDirect
  83. Peripheral nerve regeneration and neurotrophic factors. Journal of Neuroscience. J Neurosci
  84. Exercise and neuroplasticity — physiological mechanisms. Journal of Applied Physiology. J Applied Physiology
  85. Educational video resources — multiple sclerosis and nutrition. YouTube. YouTube
  86. Vitexin — neuroprotective and anti-neuroinflammatory properties. Europe PMC. Europe PMC
  87. In Vivo Assessment of the Ameliorative Impact of Some Medicinal Plant Extracts on Lipopolysaccharide-Induced Multiple Sclerosis in Wistar Rats. Molecules. PMC
  88. Vitexin bioavailability and neuroprotective mechanisms. Journal of Pharmaceutical Sciences. JPSR
  89. A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders. Planta Med. PubMed
  90. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomed Res. PubMed
  91. Hericium erinaceus mycelium and its small bioactive compounds promote oligodendrocyte maturation with an increase in myelin basic protein. Sci Rep. PubMed
  92. The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol Zh (1994). PubMed
  93. Wolfman C et al. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacology, biochemistry, and behavior. 1994. PubMed
  94. Medina JH et al. Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochemical pharmacology. 1990. PubMed
  95. Janda K et al. Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review. Nutrients. 2020. PubMed
  96. Velasquez ACA et al. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial. Oral and maxillofacial surgery. 2024. PubMed
  97. Ngan A et al. A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Phytotherapy research : PTR. 2011. PubMed
  98. Miyasaka LS et al. Passiflora for anxiety disorder. The Cochrane database of systematic reviews. 2007. PubMed
  99. Mori K et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biological & pharmaceutical bulletin. 2008. PubMed
  100. Chiu CH et al. Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. International journal of molecular sciences. 2018. PubMed
  101. Spangenberg ET et al. Unveiling the role of erinacines in the neuroprotective effects of Hericium erinaceus: a systematic review in preclinical models. Frontiers in pharmacology. 2025. PubMed
  102. Vigna L et al. Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?. Evidence-based complementary and alternative medicine : eCAM. 2019. PubMed
  103. Koszła O et al. Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies. Journal of ethnopharmacology. 2025. PubMed
  104. Roda E et al. Cognitive Healthy Aging in Mice: Boosting Memory by an Ergothioneine-Rich Hericium erinaceus Primordium Extract. Biology. 2023. PubMed
  105. Ratto D et al. Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging. Nutrients. 2019. PubMed
  106. Priori EC et al. Hericium erinaceus Extract Exerts Beneficial Effects on Gut-Neuroinflammaging-Cognitive Axis in Elderly Mice. Biology. 2023. PubMed
  107. Kasaragod VB et al. Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission. Proceedings of the National Academy of Sciences of the United States of America. 2020. PubMed
Zenius Labs™

Vitexin 90 - brain protection + nerve support

Vitexin 90 by Zenius Labs\u2122 combines vitexin (studied for protecting the brain, trialled in MS) with concentrated Hericium erinaceus polysaccharides (studied for NGF and myelin) - the two compounds discussed here. Informational only; does not replace prescribed MS treatment.

Discover Vitexin 90