HomeCholesterolWhat Lowers Cholesterol
In brief

Phytosterols — are they really safe?

Phytosterols were long seen as cholesterol’s enemy — they compete with cholesterol for absorption in the gut and so reduce how much enters the blood. But recent research reveals the other, far more dangerous side of the coin.

The problem is that phytosterols do not just block cholesterol absorption — they themselves enter the blood and accumulate in the artery walls. The enzyme ACAT, which safely “neutralises” cholesterol inside macrophages by turning it into esters, cannot recognize phytosterols. So phytosterols build up in free form, destroy macrophages faster, and accelerate the formation of atherosclerotic plaque.

This is not just theory. There is a genetic disease — sitosterolemia — in which the body’s phytosterol-clearance system (the ABCG5/ABCG8 transporters) fails. Sufferers face fatal cardiovascular complications in their youth, even with normal cholesterol levels. The large PROCAM study (20,000 participants) showed that people with the highest blood phytosterol concentrations had a 1.8-fold higher risk of heart attack. A 2022 genetic study published in Nature Communications confirmed a causal link between phytosterols and coronary heart disease.

This is exactly why the UK’s NICE does not recommend phytosterols for heart-disease prevention, and the German Cardiac Society warns of their possible atherogenic effect.

Instead of phytosterol-“enriched” products or, worse, phytosterol supplements, choose natural alternatives — for example, quality wild fatty fish. It reduces inflammation and does not deposit dangerous substances in the arteries.

Avoiding hydrogenated fats lowers cholesterol

A great deal of research has conclusively linked hydrogenated fats to heart disease, inflammation, higher bad cholesterol and lower good cholesterol.

Where are these “killer” fats found? The main sources are fast food, snacks (crisps, coated nuts and other convenience foods), fried food and baked goods (buns, doughnuts). They are also found at around 5–10% in the meat of grass-fed cattle and in dairy products (butter, cheese, sour cream, curd, yoghurt and so on).

As the table shows, we get the most hydrogenated fats from baked goods, and in second place from dairy products.

You have probably noticed that pure, cold mechanically first-pressed oil contains no hydrogenated fats — nor do pork lard, eggs or fatty poultry (goose, duck and the like).

Cut out the unhealthy products (from the table) and that will lower your cholesterol.

Tasty everyday foods that lower cholesterol

To keep good cholesterol (and physical health), you have to take responsibility for what you eat at every meal, every day. Fish (herring, mackerel and others where possible), nuts, seeds, seafood and pure (unheated, unfried, unprocessed) plant oils are needed in abundance on the daily table. These are the foods that lower the bad cholesterol and improve your circulation.

Quitting smoking lowers cholesterol

Cigarette smoking lowers the good cholesterol, which is especially important because it helps clear the bad cholesterol from the arteries. If you smoke, you are rapidly adding to a higher bad-cholesterol level and heading straight for the heart-disease clinic.

Did you know there is an easy way to quit smoking?

Abstaining from alcohol lowers cholesterol

Although alcohol itself contains no cholesterol, drinking it has a negative effect and raises the cholesterol level. Alcohol is broken down in the liver and reassembled as cholesterol, which is especially harmful to your health. We were misled into believing that “a little alcohol is good,” but research warns that there is no safe amount of alcohol at all.

Give up sweets and you will lower cholesterol

Sugar is perhaps the single greatest harm to your health, wrecking the circulatory system. Most people eat too much sweetness, because they so love the products rich in it — fruit, honey, sweet soft drinks, juices, sweets, biscuits, cakes, buns, curd snacks. The less sweetness (fructose, glucose, sucrose, lactose and other sugars) we consume, the more it lowers cholesterol and improves health, energy levels and quality of life.

It is worth noting that scientists have shown sugar is no less addictive than certain drugs, so quitting is not so easy.

Every time before you reach for a chocolate, a bun or a lemonade, remember — this is a way of knowingly harming yourself. Choose to love yourself and cut sugar to a minimum, or to zero.

Take supplements that help lower cholesterol without side effects

One of the most effective supplements is medicinal mushrooms. Scientists have shown that the active compounds in certain mushrooms can be far more effective than the cholesterol drugs found in pharmacies. This is because some medicinal mushrooms naturally restore cholesterol balance rather than simply blocking its production. Best of all, you can be safe taking these natural supplements, since they do not carry the 10–20 negative side effects. So which are the best cholesterol supplements?

Which medicinal mushrooms lower cholesterol without side effects?

There are medicinal mushrooms that not only lower the bad cholesterol but also raise the good, restoring the cholesterol norm. These dry polysaccharide extracts go into the best cholesterol supplements.

Related supplement

Mushroom polysaccharides are studied as lowering cholesterol similarly to statins without side effects. A concentrated multi-extract formula is needed.

AURI 25 by Zenius Labs™ →

Frequently Asked Questions

Which foods most effectively lower cholesterol?

The most effective are wild fatty fish (omega-3), nuts, avocados and fermented foods. Even more important is removing what raises cholesterol — sugar, refined carbohydrates and hydrogenated (trans) fats.

Do mushroom polysaccharides really help lower cholesterol?

Research shows mushroom polysaccharides can lower cholesterol with effectiveness similar to statins, without the side effects. However, simple mushroom powders are too weak — a concentrated multi-extract formula such as AURI 25 by Zenius Labs™ is needed.

Are phytosterols safe for lowering cholesterol?

Recent research raises concerns: phytosterols can themselves enter the blood and accumulate in artery walls. The UK NICE institute does not recommend them for heart-disease prevention, and the German Cardiac Society warns of a possible atherogenic effect. Natural alternatives such as wild fatty fish are preferable.

Does alcohol affect cholesterol?

Yes. Alcohol is processed by the liver — the same organ that produces and regulates cholesterol. Excess alcohol raises triglycerides and can disrupt the cholesterol balance, so reducing or abstaining helps.

References
  1. Cholesterol management guide. WebMD
  2. PubMed 22098807 — Obesity and physical activity. PubMed
  3. PubMed 32741068 — Physical activity and cancer prevention. PubMed
  4. PubMed 21076975 — Exercise and depression. PubMed
  5. PubMed 32104516 — Physical activity guidelines. PubMed
  1. PubMed 27168471 — Diet and cholesterol. PubMed
  2. PubMed 10593643 — Dietary fiber and cholesterol. PubMed
  3. PubMed 8153500 — Soluble fiber and lipids. PubMed
  4. PubMed 20407058 — Sugar and dyslipidemia. PubMed
  5. Cardiovascular health. NHLBI
  6. Health research — cholesterol. CNN
  7. Halbert SC et al. Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance. The American journal of cardiology. 2010. PubMed
  8. Brown AS et al. Statin Intolerance. Reviews in cardiovascular medicine. 2018. PubMed
  9. Riaz H et al. Meta-analysis of Placebo-Controlled Randomized Controlled Trials on the Prevalence of Statin Intolerance. The American journal of cardiology. 2017. PubMed
  10. Ahmad K et al. Effectiveness of Coenzyme Q10 Supplementation in Statin-Induced Myopathy: A Systematic Review. Cureus. 2024. PubMed
  11. Fitzgerald K et al. Statin-induced Myopathy. Global advances in health and medicine. 2012. PubMed
  12. Gong J et al. Efficacy and safety of sugarcane policosanol on dyslipidemia: A meta-analysis of randomized controlled trials. Molecular nutrition & food research. 2018. PubMed
  13. Chen JT et al. Meta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol. Pharmacotherapy. 2005. PubMed
  14. Millán J et al. Effects of a nutraceutical combination containing berberine (BRB), policosanol, and red yeast rice (RYR), on lipid profile in hypercholesterolemic patients: A meta-analysis of randomised controlled trials. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis. 2016. PubMed
  15. Singh DK et al. Policosanol inhibits cholesterol synthesis in hepatoma cells by activation of AMP-kinase. The Journal of pharmacology and experimental therapeutics. 2006. PubMed
  16. Castaño G et al. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clinical drug investigation. 2003. PubMed
  17. Xiong Z et al. An overview of the bioactivity of monacolin K / lovastatin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019. PubMed
  18. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) et al. Scientific Opinion on additional scientific data related to the safety of monacolins from red yeast rice submitted pursuant to Article 8(4) of Regulation (EC) No 1925/2006. EFSA journal. European Food Safety Authority. 2025. PubMed
  19. Angelopoulos N et al. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial. Nutrients. 2023. PubMed
  20. Trimarco B et al. Clinical evidence of efficacy of red yeast rice and berberine in a large controlled study versus diet. Mediterranean journal of nutrition and metabolism. 2011. PubMed
  21. González-Bonilla A et al. Dietary Supplementation with Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), Reduces Visceral Fat and Hyperlipidemia in Inhabitants of a Rural Community in Mexico. International journal of medicinal mushrooms. 2022. PubMed
  22. Abrams DI et al. Antihyperlipidemic effects of Pleurotus ostreatus (oyster mushrooms) in HIV-infected individuals taking antiretroviral therapy. BMC complementary and alternative medicine. 2011. PubMed
  23. Zhang Y et al. Pleurotus abieticola Polysaccharide Alleviates Hyperlipidemia Symptoms via Inhibition of Nuclear Factor-κB/Signal Transducer and Activator of Transcription 3-Mediated Inflammatory Responses. Nutrients. 2023. PubMed
  24. Du H et al. Dietary intake of whole king oyster mushroom (Pleurotus eryngii) attenuated obesity via ameliorating lipid metabolism and alleviating gut microbiota dysbiosis. Food research international (Ottawa, Ont.). 2024. PubMed
  25. Yoon SJ et al. The nontoxic mushroom Auricularia auricula contains a polysaccharide with anticoagulant activity mediated by antithrombin. Thrombosis research. 2003. PubMed
  26. Bian C et al. A Novel Polysaccharide from AuriculariaAuricula Alleviates Thrombosis Induced by Carrageenan in Mice. Molecules (Basel, Switzerland). 2022. PubMed
  27. Shi Q et al. Isolation, Characterization, and Antioxidant Activity of Melanin from Auricularia auricula (Agaricomycetes). International journal of medicinal mushrooms. 2023. PubMed
  28. Yin CM et al. Physicochemical Properties and Antioxidant Activity of Natural Melanin Extracted from the Wild Wood Ear Mushroom, Auricularia auricula (Agaricomycetes). International journal of medicinal mushrooms. 2022. PubMed
  29. Liu X et al. Comprehensive utilization of edible mushroom Auricularia auricula waste residue-Extraction, physicochemical properties of melanin and its antioxidant activity. Food science & nutrition. 2019. PubMed
  30. Pirro M et al. The effects of a nutraceutical combination on plasma lipids and glucose: A systematic review and meta-analysis of randomized controlled trials. Pharmacological research. 2016. PubMed
  31. Iskandar I et al. Efficacy and tolerability of a nutraceutical combination of red yeast rice, guggulipid, and chromium picolinate evaluated in a randomized, placebo-controlled, double-blind study. Complementary therapies in medicine. 2020. PubMed
  32. Garoufi A et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024. PubMed
  33. Protic O et al. Nutraceutical Combinations in Hypercholesterolemia: Evidence from Randomized, Placebo-Controlled Clinical Trials. Nutrients. 2021. PubMed
  34. Trimarco V et al. Effects of a new combination of nutraceuticals with Morus alba on lipid profile, insulin sensitivity and endotelial function in dyslipidemic subjects. A cross-over, randomized, double-blind trial. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension. 2015. PubMed
  35. Hoogeveen RC et al. Residual Cardiovascular Risk at Low LDL: Remnants, Lipoprotein(a), and Inflammation. Clinical chemistry. 2021. PubMed
  36. Bashir B et al. Beyond LDL-C: unravelling the residual atherosclerotic cardiovascular disease risk landscape-focus on hypertriglyceridaemia. Frontiers in cardiovascular medicine. 2024. PubMed
  37. Soran H et al. Optimising treatment of hyperlipidaemia: Quantitative evaluation of UK, USA and European guidelines taking account of both LDL cholesterol levels and cardiovascular disease risk. Atherosclerosis. 2018. PubMed
  38. Chapman MJ Therapeutic elevation of HDL-cholesterol to prevent atherosclerosis and coronary heart disease. Pharmacology & therapeutics. 2006. PubMed